catR [2017-05-17 11:12:48]

MarR/DUF24 family transcription repressor of the catD-catE operon

locus: BSU33680

pI: 9.89

mw: 26.99 kDa

protein length: 236 aa

gene length: 708 bp

function: resistance against oxidative and electrophile stress

product: MarR/DUF24 family transcription repressor

essential: no

synonyms: yvaP

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

Gene

Coordinates: 3,457,615 → 3,457,941

Phenotypes of a mutant

• increased resistance to catechol and quinones [Pubmed|20639328]

The protein

Catalyzed reaction/ biological activity

• [[MarR/DUF24 family]] transcription repressor of the'' [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE]'' operon [Pubmed|20639328]

Protein family

• [[MarR/DUF24 family]]

Paralogous protein(s)

• [protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|YodB]

Modification

• in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of ''[gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE]'') [Pubmed|20639328]

Expression and Regulation

Operons

• genes: [gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-A451 (yvaP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/451 NBRP B. subtilis, Japan]

Labs working on this gene/protein

• [SW|Haike Antelmann],University of Greifswald, Germany

References

• 18282125